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Could Low Vitamin D Status Impair Cognitive Function? In a retrospective review at a university-affiliated clinic, researchers sought to assess whether vitamin D plays a significant role in preserving cognitive function. Vitamin D deficiency is known to cause classical diseases such as rickets and osteomalacia, and has been correlated in a number of studies with bone health parameters. Investigators in this study note that subclinical vitamin D status has also been linked with cancer, diabetes and multiple sclerosis. They postulate that because of vitamin D’s presence in neural tissue, deficiency may impede cognition. Vitamin B12 (known to effect cognitive function) was also assessed. Researchers conducted a correlation analysis of data from a group of 32 older adults receiving assessment for memory loss and behavior problems relating to cognitive impairment, together with blood samples taken to ascertain nutritional status. Specifically, a mini-mental state examination MMSE score was assessed relative to serum 25-hydroxyvitamin D (25(OH)D) and vitamin B12 levels. Blood samples were taken within 6 hours of cognitive testing. Researchers note a positive correlation of serum 25(OH)D and MMSE scores (p= 0.0006), and no correlation between B12 and MMSE scores ( p= 0.875). Investigators cite that while no consensus has been established, at the time of their research serum 25(OH)D levels below 30 ng/ml are considered suboptimal. Based on these parameters, 78% of test subjects were considered deficient in vitamin D. Researchers note a number of possible mechanisms accounting for the effect of vitamin D on cognitive functioning and its possible role in neuroprotection. While they are careful to note that these findings do not prove a causative link between vitamin D status and impaired cognitive function, Przybelski et al assert that if a causative association is established, vitamin D supplementation may present a low cost, beneficial option for patients suffering from memory loss or neurodegenerative disorders. Study: Przybelski R. J., et al, Archives of Biochemistry and Biophysics 460: 202-205, (2007) RETURN from vitamin d and cognitive function study |
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